Study discovered the genetic causes that made it possible for humans to evolve from knuckle-rolling to the upright walking of modern humans. The report, published in the journal Science, explains why development From the genetic architecture of man, he became bipedal.
The study was conducted through a combination of the linkage between the entire human genome and artificial intelligence, which allowed the creation of the first map of the genomic regions responsible for the modifications that the skeleton of monkeys underwent and that led to the upright walking of modern humans. Tarjinder Singh, co-director of the study, explained: “On a practical level, we also identified genetic variants and skeletal features associated with osteoarthritis of the hip, knee, and back, which are the leading causes of disability in adults in the United States.”
The latter, Singh, accounted for slight deviations of the hip, both in width and height, that can be associated with a greater risk of osteoporosis. Data that enables researchers to develop ideas for prevention and treatment of these diseases.
From nearly 30,000 X-rays, they scanned the human genome with the goal of identifying chromosomal regions associated with changes in 23 skeletal measurements. These included shoulder width, torso length, and the angle between the tibia and femur. This work revealed that there are 145 regions associated with genes that are regulated development of sorts.
“What we’re seeing is the first genetic evidence of a selective pressure on genetic variants affecting skeletal dimensions, which allowed the transition from knuckle-toeing to bipedal walking,” said Vagish M. Narasimhan, co-director of the study. Discovery.
Through this work, the specialists were able to detail that the most profound change in development From primates it happened about 6 million years ago. At that time, by “independent” hands, and stop using them for movement, human ancestors could begin to use tools and have greater cognitive development.