Researchers identify signs of anxiety associated with Parkinson’s disease

Parkinson’s disease is a type of movement disorder.

The results of spectroscopy showed an association between anxiety and changes in alpha activity in the right frontal cortex.

The intrinsic cortex and frontal cortex are involved in the development of anxiety in adults with Parkinson’s disease. Parkinson’s DiseaseAccording to data from the published Neurophysiology Clinic study, researchers found that anxiety occurs in approximately 31% of Alzheimer’s patients. Parkinson’s Diseasebut the underlying mechanisms are not well understood.

Nassim Batrouni, MD, of the University of Lille in France, and colleagues confirmed that it is similar to other research that has shown an association between anxiety severity and increased activity in areas of the brain that process emotion, according to MRI and PET scans, but they said electroencephalography (EEG) Not widely used.

In the process, the researchers compared EEG spectral patterns and resting-state functional networks in affected patients Parkinson’s Disease With and without anxiety disorders. They identified data from 33 patients with Parkinson’s disease who met the criteria for anxiety and 75 without anxiety. The mean age of patients was 65 years, and the mean duration of illness was 9.76 years in anxious patients and 7.83 years in non-anxious patients.

Overall, the spectroscopy results showed an association between anxiety and changes in alpha activity in the right frontal cortex, the researchers said. They also found that relative strengths in the alpha1 frequency band in the right prefrontal cortex were lower in anxious patients than in those without.

This result was significantly associated with avoidance behavior on a subscale of the anxiety scale Parkinson’s Disease. A trend toward a significant association with episodic anxiety was observed, but no significant associations for persistent anxiety or total scale score were observed.

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The researchers said the images also showed increased connectivity between the posterior cingulate cortex and the posterior cingulate cortex at different frequency bands in anxiety patients. They noted that “the increased connectivity observed here may be a sign of the maintenance of avoidance behaviors that characterize anxiety in PD.”

The study is the first to use EEG to explore anxiety mechanisms related to Parkinson’s and the “reported findings provide new insights, support findings from previous studies using other modalities, primarily rs-fMRI, and show that EEG can be relevant.” “A technique for exploring these disorders,” the researchers wrote.

However, more is needed Research To confirm the results in patients with a broader range of anxiety disorders, they concluded.

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