High-dose versus low-dose exercise in patients with osteoarthritis of the knee Articles

Patients in the low and high dose groups improved significantly at 3 months


  • The authors of this randomized, multicenter trial explored the optimal dose of exercise for patients with osteoarthritis of the knee with long-term symptoms. Of the 189 patients with knee osteoarthritis included in the study, 98 patients were randomized to treatment with high-dose exercise (70 to 90 minutes) and 91 to treatment with low-dose exercise (20 to 30 minutes).
  • Outcomes for patients in the low and high dose groups improved significantly at 3 months. In general, the low- and high-dose exercise groups showed similar improvement, except for sport, recreational function, and quality of life, which improved slightly in the high-dose group.
  • These data do not support the superiority of high-dose exercise therapy over low-dose exercise therapy for symptomatic knee osteoarthritis.


High dose versus low dose exercise therapy in osteoarthritis of the knee


The benefits of exercise in patients with osteoarthritis of the knee have been well documented, but the optimal dose of exercise is still unknown.


To compare high-dose versus low-dose exercise therapy with regard to knee function, pain, and quality of life (QoL) in subjects with symptomatic long-term symptomatic knee osteoarthritis.


A Swedish and Norwegian multicenter randomized controlled trial of superiority with multiple follow-up up to 12 months post-intervention. (ClinicalTrials.gov: NCT02024126)


Primary health care institutions.


189 patients with diagnosed knee osteoarthritis and a history of knee pain and decreased function were assigned to either high-dose treatment (n = 98; 11 exercises; 70 to 90 minutes) or low-dose treatment (n = 91; 5 exercises; 20 to 30 minutes). .

to intervene:

Exercise programs adapted to the patient according to the principles of medical exercise therapy. Global (aerobic), semi-universal (multi-part), and local (joint-specific) exercises were performed 3 times per week for 12 weeks under the supervision of a physical therapist.


The knee injury and osteoarthritis score (KOOS) was measured every two weeks during the 3-month intervention period and at 6 and 12 months after the intervention.

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Aileen Morales

"Beer nerd. Food fanatic. Alcohol scholar. Tv practitioner. Writer. Troublemaker. Falls down a lot."

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