Patients in the low and high dose groups improved significantly at 3 months
High dose versus low dose exercise therapy in osteoarthritis of the knee
The benefits of exercise in patients with osteoarthritis of the knee have been well documented, but the optimal dose of exercise is still unknown.
To compare high-dose versus low-dose exercise therapy with regard to knee function, pain, and quality of life (QoL) in subjects with symptomatic long-term symptomatic knee osteoarthritis.
A Swedish and Norwegian multicenter randomized controlled trial of superiority with multiple follow-up up to 12 months post-intervention. (ClinicalTrials.gov: NCT02024126)
Primary health care institutions.
189 patients with diagnosed knee osteoarthritis and a history of knee pain and decreased function were assigned to either high-dose treatment (n = 98; 11 exercises; 70 to 90 minutes) or low-dose treatment (n = 91; 5 exercises; 20 to 30 minutes). .
Exercise programs adapted to the patient according to the principles of medical exercise therapy. Global (aerobic), semi-universal (multi-part), and local (joint-specific) exercises were performed 3 times per week for 12 weeks under the supervision of a physical therapist.
The knee injury and osteoarthritis score (KOOS) was measured every two weeks during the 3-month intervention period and at 6 and 12 months after the intervention.